Empedocles also applied the four elements to medicine. He said that normally, the body had a balance of the elements; disease was brought on by an unbalance of the elements. This was later expanded to be the four liquids, or humours: phlegm, blood, black bile, and yellow bile. Water was associated with phlegm, air with yellow bile, earth with black bile, and fire with blood.
The four humours were so widely accepted that we have many words derived from them today. Humour, in the sense of a disposition, comes from the humours. Phlegmatic means stolid and unemotional; sanguine (from the Latin word for blood) means cheerful and optimistic; melancholic (from black bile) means depressed; and choleric (from yellow bile) means angry. These words come from the supposed affects of the humours on someone's attitude.
Bibliography
Youngson, Robert. Scientific Blunders. New York: Carroll and Graf Publishers, Inc., 1998.
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